Rates of more than a dozen cancers are increasing among adults under 50 worldwide, with the number of early-onset cancer cases predicted to rise by around 30% between 2019 and 2030. Investigators are searching for explanations, considering factors such as obesity, early-cancer screening, gut microbiome, and tumor genomes. Despite increased screening and awareness, mortality from early-onset cancers has risen by nearly 28% between 1990 and 2019 globally.

12P/Pons-Brooks, a Halley-type comet larger than Mount Everest and with a 71.3-year orbit, is expected to become visible to the naked eye in the coming weeks as it makes its closest approach to the sun on April 21. The Guardian reports: While some reports suggest 12P/Pons-Brooks was spotted as far back as the 14th century, it is named after the French astronomer Jean-Louis Pons who discovered it in 1812 and the British-American astronomer William Robert Brooks who observed it on its next orbit in 1883. Thought to have a nucleus about 30km (20 miles) in diameter, it is classed as a cryovolcanic comet, meaning it erupts with dust, gases and ice when pressure builds inside as it is heated. One such outburst last year caused it to brighten a hundredfold and garnered it the sobriquet of "the Devil Comet" after the haze that surrounds it formed a horned shape.

While the comet -- and its green tinge -- has already been spotted in the night sky, experts say it is expected to become even brighter in the coming weeks. "The comet is expected to reach a magnitude of 4.5 which means it ought to be visible from a dark location in the UK," said Dr Paul Strom, an astrophysicist at the University of Warwick. "The comet moves from the constellation of Andromeda to Pisces. As it does so it passes by bright stars which will make it easier to spot on certain dates. In particular, on March 31 12P/Pons-Brooks will be only 0.5 a degree from the bright star called Hamal," he said. But Dr Robert Massey, the deputy executive director of the Royal Astronomical Society, said even if the comet did become brighter it could still be difficult to see, adding that basic instruments such as small telescopes would greatly help.

"If you have a half-decent pair of binoculars, certainly attempt to look for it with those," said Massey, adding that apps that map the sky were also useful. The best views of the comet are currently to be found in the northern hemisphere. Massey said those who wanted to catch a glimpse should venture out on a clear evening and look low in the west-north-west as twilight came to an end. "You want to avoid haze, you want to avoid moonlight, you want to avoid light pollution."

An anonymous reader quotes a report from Inside Climate News: Months in jail and thousands of dollars in fines and legal fees -- those are the consequences Alabamians and Arizonans could soon face for selling cell-cultured meat products that could cut into the profits of ranchers, farmers and meatpackers in each state. State legislators from Florida to Arizona are seeking to ban meat grown from animal cells in labs, citing a "war on our ranching" and a need to protect the agriculture industry from efforts to reduce the consumption of animal protein, thereby reducing the high volume of climate-warming methane emissions the sector emits. Agriculture accounts for about 11 percent of the country's greenhouse gas emissions, according to federal data, with livestock such as cattle making up a quarter of those emissions, predominantly from their burps, which release methane -- a potent greenhouse gas that's roughly 80 times more effective at warming the atmosphere than carbon dioxide over 20 years. Globally, agriculture accounts for about 37 percent of methane emissions.

For years, climate activists have been calling for more scrutiny and regulation of emissions from the agricultural sector and for nations to reduce their consumption of meat and dairy products due to their climate impacts. Last year, over 150 countries pledged to voluntarily cut emissions from food and agriculture at the United Nations' annual climate summit. But the industry has avoided increased regulation and pushed back against efforts to decrease the consumption of meat, with help from local and state governments across the U.S.

Bills in Alabama, Arizona, Florida and Tennessee are just the latest legislation passed in statehouses across the U.S. that have targeted cell-cultured meat, which is produced by taking a sample of an animal's muscle cells and growing them into edible products in a lab. Sixteen states -- Alabama, Arkansas, Georgia, Kansas, Kentucky, Louisiana, Maine, Mississippi, Missouri, Montana, North Dakota, Oklahoma, South Carolina, South Dakota, Texas and Wyoming -- have passed laws addressing the use of the word "meat" in such products' packaging, according to the National Agricultural Law Center at the University of Arkansas, with some prohibiting cell-cultured, plant-based or insect-based food products from being labeled as meat.

Jennifer Ouellette reports via Ars Technica: Astronomers have made new measurements of the Hubble Constant, a measure of how quickly the Universe is expanding, by combining data from the Hubble Space Telescope and the James Webb Space Telescope. Their results confirmed the accuracy of Hubble's earlier measurement of the constant's value, according to their recent paper published in The Astrophysical Journal Letters, with implications for a long-standing discrepancy in values obtained by different observational methods known as the "Hubble tension."

There was a time when scientists believed the Universe was static, but that changed with Albert Einstein's general theory of relativity. Alexander Friedmann published a set of equations showing that the Universe might actually be expanding in 1922, with Georges Lemaitre later making an independent derivation to arrive at that same conclusion. Edwin Hubble confirmed this expansion with observational data in 1929. Prior to this, Einstein had been trying to modify general relativity by adding a cosmological constant in order to get a static universe from his theory; after Hubble's discovery, legend has it, he referred to that effort as his biggest blunder. The article notes how scientists have employed different methods to calculate the Hubble Constant, including observing nearby celestial objects, analyzing gravitational waves from cosmic events, and examining the Cosmic Microwave Background (CMB). However, these approaches yield differing values, highlighting the challenge in pinning down the constant precisely. A recent effort involved making additional observations of Cepheid variable stars, correlating them with the Hubble data. The results further confirmed the accuracy of the Hubble data.

"We've now spanned the whole range of what Hubble observed, and we can rule out a measurement error as the cause of the Hubble Tension with very high confidence," said co-author and team leader Adam Riess, a physicist at Johns Hopkins University. "Combining Webb and Hubble gives us the best of both worlds. We find that the Hubble measurements remain reliable as we climb farther along the cosmic distance ladder. With measurement errors negated, what remains is the real and exciting possibility that we have misunderstood the Universe."

The openVertebrate (oVert) project is now complete, offering free online access to incredibly detailed 3D images of over 13,000 vertebrates. New Atlas reports: More than a research project, oVert was a collaboration between like-minded specialists across 25 institutions whose sole objective was to add value to museum collections by making them more widely available. Importantly, these images provide an insight that would only otherwise be obtained by destructive dissection and tissue sampling. Over the course of six years, project members took CT scans of more than half the classes, or genera, of all amphibians, reptiles, fishes, birds, and mammals, rendering models that provide an intimate look at the creatures, inside and out. [...]

For a working example of the incredible detail and information contained in oVert's images, head to Sketchfab to view a sample of interactive 3D models like the olive sea snake. Or go to MorphoSource to access the full oVert repository. [...] If you have 30 minutes to spare, check out the full video produced by the Florida Museum, which showcases a collection of diverse oVert specimens. A study presenting a summary of the oVert project was published in the journal BioScience.

Surgeons in the United Kingdom have performed the first operation in the country using Apple's Vision Pro headset. TechSpot reports: During a recent operation to repair a patient's spine at the private Cromwell Hospital in London, a scrub nurse working alongside the surgeon used the Vision Pro to help prepare, keep track of the procedure, and choose the right tools, reports the Daily Mail. This marked the first operation in the UK where the Vision Pro was used. The software running on Apple's headset during the operation comes from US company eXeX, which has made similar programs for Microsoft's HoloLens. It offers nurses and technicians both holographic and touch-free access to the surgical setup and the procedural guides from within the sterile field of the operating room, according to the press release. The software also tracks each stage of an operation and can measure how well the op went compared to previous procedures performed by other surgeons.

"It eliminates human error and eliminates the guesswork," said Suvi Verho, lead scrub nurse at London Independent Hospital. "It gives you confidence in surgery." While this marked the first time that the Vision Pro was used during a UK surgery, the first-ever time the device was used in an operating room was last month, just three days after its release, when Orlando resident and world-renowned Neurosurgeon Dr. Robert Masson wore it during several spine reconstruction surgeries. "We are in a new era of surgery, and for the first time, our surgical teams have the brilliance of visual holographic guidance and maps, improving visuospatial and temporal orientation for each surgical team and for each surgery in all specialties," said Masson.

CNN's national security analyst interviewed a U.S. intelligence officer who worked on the newly-released Defense report debunking UFO sightings — physicist Sean Kirkpatrick. He tells CNN "about two to five percent" of UFO reports are "truly anomalous."

But CNN adds that "he thinks explanations for that small percentage will most likely be found right here on Earth..." This is how Kirkpatrick and his team explain the Roswell incident, which plays a prominent role in UFO lore. That's because, in 1947, a U.S. military news release stated that a flying saucer had crashed near Roswell Army Air Field in New Mexico. A day later, the Army retracted the story and said the crashed object was a weather balloon. Newspapers ran the initial saucer headline, followed up with the official debunking, and interest in the case largely died down. Until 1980, that is, when a pair of UFO researchers published a book alleging that alien bodies had been recovered from the Roswell wreckage and that the U.S. government had covered up the evidence.

Kirkpatrick says his office dug deep into the Roswell incident and found that in the late 1940s and early 1950s, there were a lot of things happening near the Roswell Airfield. There was a spy program called Project Mogul, which launched long strings of oddly shaped metallic balloons. They were designed to monitor Soviet nuclear tests and were highly secret. At the same time, the U.S. military was conducting tests with other high-altitude balloons that carried human test dummies rigged with sensors and zipped into body-sized bags for protection against the elements. And there was at least one military plane crash nearby with 11 fatalities.

Echoing earlier government investigations, Kirkpatrick and his team concluded that the crashed Mogul balloons, the recovery operations to retrieve downed test dummies and glimpses of the charred aftermath of that real plane crash likely combined into a single false narrative about a crashed alien spacecraft...

Since 2020, the Pentagon has standardized, de-stigmatized and increased the volume of reporting on UFOs by the U.S. military. Kirkpatrick says that's the reason the closely covered and widely-mocked Chinese spy balloon was spotted in the first place last year. The incident shows that the U.S. government's policy of taking UFOs seriously is actually working.
The pattern keeps repeating. "Kirkpatrick says, his investigation found that most UFO sightings are of advanced technology that the U.S. government needs to keep secret, of aircraft that rival nations are using to spy on the U.S. or of benign civilian drones and balloons." ("What's more likely?" asked Kirkpatrick. "The fact that there is a state-of-the-art technology that's being commercialized down in Florida that you didn't know about, or we have extraterrestrials?")

But the greatest irony may be that "stories about these secret programs spread inside the Pentagon, got embellished and received the occasional boost from service members who'd heard rumors about or caught glimpses of seemingly sci-fi technology or aircraft. And Kirkpatrick says his investigators ultimately traced this game of top-secret telephone back to fewer than a dozen people... [F]or decades, UFO true believers have been telling us there's a U.S. government conspiracy to hide evidence of aliens. But — if you believe Kirkpatrick — the more mundane truth is that these stories are being pumped up by a group of UFO true believers in and around government."

Science magazine "has confirmed that a panel of two dozen geologists has voted down a proposal to end the Holocene — our current span of geologic time, which began 11,700 years ago at the end of the last ice age — and inaugurate a new epoch, the Anthropocene.

"Starting in the 1950s, it would have marked a time when humanity's influence on the planet became overwhelming." The vote, first reported by The New York Times, is a stunning — though not unexpected — rebuke for the proposal, which has been working its way through a formal approval process for more than a decade... [S]ome felt the proposed marker of the epoch — some 10 centimeters of mud from Canada's Crawford Lake that captures the global surge in fossil fuel burning, fertilizer use, and atomic bomb fallout that began in the 1950s — isn't definitive enough. Others questioned whether it's even possible to affix one date to the start of humanity's broad planetary influence: Why not the rise of agriculture? Why not the vast changes that followed European encroachment on the New World?
Stanley Finney, a stratigrapher at California State University Long Beach and head of the International Union of Geological Sciences, said "It would have been rejected 10 years earlier if they had not avoided presenting it to the stratigraphic community for careful consideration." Finney also complains that from the start, AWG was determined to secure an "epoch" categorization, and ignored or countered proposals for a less formal Anthropocene designation.... The Anthropocene backers will now have to wait for a decade before their proposal can be considered again...

Even if it is not formally recognized by geologists, the Anthropocene is here to stay. It is used in art exhibits, journal titles, and endless books... And others have advanced the view that it can remain an informal geologic term, calling it the "Anthropocene event...."
From the New York Times: Geoscientists don't deny our era stands out within that long history. Radionuclides from nuclear tests. Plastics and industrial ash. Concrete and metal pollutants. Rapid greenhouse warming. Sharply increased species extinctions. These and other products of modern civilization are leaving unmistakable remnants in the mineral record, particularly since the mid-20th century. Still, to qualify for its own entry on the geologic time scale, the Anthropocene would have to be defined in a very particular way, one that would meet the needs of geologists and not necessarily those of the anthropologists, artists and others who are already using the term.

That's why several experts who have voiced skepticism about enshrining the Anthropocene emphasized that the vote against it shouldn't be read as a referendum among scientists on the broad state of the Earth. "This was a narrow, technical matter for geologists, for the most part," said one of those skeptics, Erle C. Ellis, an environmental scientist at the University of Maryland, Baltimore County. "This has nothing to do with the evidence that people are changing the planet," Dr. Ellis said. "The evidence just keeps growing."

Francine M.G. McCarthy, a micropaleontologist at Brock University in St. Catharines, Ontario, is the opposite of a skeptic: She helped lead some of the research to support ratifying the new epoch. "We are in the Anthropocene, irrespective of a line on the time scale," Dr. McCarthy said. "And behaving accordingly is our only path forward."
Thanks to Slashdot reader sciencehabit for sharing the news.

An anonymous reader shared this article from the Washington Post: A much-debated theory holds that 4 billion years ago, give or take, long before the appearance of dinosaurs or even bacteria, the primordial soup contained only the possibility of life. Then a molecule called RNA took a dramatic step into the future: It made a copy of itself. Then the copy made a copy, and over the course of many millions of years, RNA begot DNA and proteins, all of which came together to form a cell, the smallest unit of life able to survive on its own.

Now, in an important advance supporting this RNA World theory, scientists at the Salk Institute for Biological Studies in La Jolla, Calif., have carried out a small but essential part of the story. In test tubes, they developed an RNA molecule that was able to make accurate copies of a different type of RNA. The work, published in the journal Proceedings of the National Academy of Sciences, gets them closer to the grand goal of growing an RNA molecule that makes accurate copies of itself.

"Then it would be alive," said Gerald Joyce, president of Salk and one of the authors of the new paper. "So, this is the road to how life can arise in a laboratory or, in principle, anywhere in the universe...."

John Chaput, a professor of pharmaceutical sciences at the University of California at Irvine who did not participate in the study, called the crossing of that threshold by the Salk team "monumental," adding that "at first, I looked on it as a little bit jaw-dropping. ... It's super-neat."
The Post adds that "the scenario they tested probably mimics one of the earliest stirrings of evolution." And Michael Kay, a professor of biochemistry at University of Utah, says the new paper has given the RNA World theory "key evidence" to show "it is plausible and reasonable." He added that the RNA copier developed at Salk will "provide a valuable tool for people wanting to do directed evolution experiments."

An anonymous Slashdot reader shared this article from Live Science: Manufacturers will no longer use harmful "forever chemicals" in food packaging products in the U.S., according to the U.S. Food and Drug Administration (FDA).

In a statement released February 28, the agency declared that grease-proofing materials that contain per- and polyfluoroalkyl substances (PFAS) will not be used in new food packaging sold in the U.S. These include PFAS used in fast-food wrappers, microwave popcorn bags, takeout boxes and pet food bags. The FDA's announcement marks the completion of a voluntary phase-out of the materials by U.S. food packaging manufacturers.

This action will eliminate the "major source of dietary exposure to PFAS," Jim Jones, deputy commissioner for human foods at the FDA, said in an associated statement. Companies told the FDA that it could take up to 18 months to completely exhaust the market supply of these products following their final date of sale. However, most of the affected manufacturers phased out the products faster than they initially predicted, the agency noted...

The FDA's new announcement marks a "huge win for the public," Graham Peaslee, a professor of physics at the University of Notre Dame who studies PFAS, told The Washington Post.

Remember Avi Loeb, the Harvard professor who claims fragments of alien technology turned up in a high-speed meteor he retrieved from the waters off of Papua, New Guinea?

"Reanalysis of seismic data now suggests Loeb may have been looking for the meteor remnants in the wrong place," writes the Washington Post: The analysis, led by seismologist Benjamin Fernando of Johns Hopkins University, contends that sound waves purportedly from the meteor exploding in the atmosphere, and cited by Loeb as helping to locate the meteor's debris field, were most likely from a truck driving on a road near the seismometer.
"Interstellar signal linked to aliens was actually just a truck," reads the headline on an announcement from Johns Hopkins University. "The fireball location was actually very far away from where the oceanographic expedition went to retrieve these meteor fragments," Fernando says in the announcement. "Not only did they use the wrong signal, they were looking in the wrong place." Using data from stations in Australia and Palau designed to detect sound waves from nuclear testing, Fernando's team identified a more likely location for the meteor, more than 100 miles from the area initially investigated. They concluded the materials recovered from the ocean bottom were tiny, ordinary meteorites — or particles produced from other meteorites hitting Earth's surface mixed with terrestrial contamination.
"There are hundreds of signals that look just like this on that seismometer in Papua New Guinea in the days before and the days after," Fernando told the Washington Post.

But the newspaper adds that "Loeb, however, stands his ground." "The seismic data is completely irrelevant to the location of the meteor," Loeb told The Washington Post. He said his team based its search coordinates primarily on satellite data from the United States military. A three-year analysis by the United States Space Command supported the hypothesis that the meteor's extreme velocity indicated an origin outside our solar system, Loeb said...

[Fernando] said his team believes the purported velocity of the meteor is the result of a measurement error by a sensor. "We think the most likely case is it's a natural meteor from within our solar system," he said.

In any case, Loeb is not done with the search. When he gets sufficient funding, he told The Post, he's going back to the Pacific in search of larger pieces of whatever splashed into the sea.

A recent survey found that academic organizations are failing to preserve digital material -- "including science paid for with taxpayer money," reports Ars Technica, highlighting the need for improved archiving standards and responsibilities in the digital age. From the report: The work was done by Martin Eve, a developer at Crossref. That's the organization that organizes the DOI system, which provides a permanent pointer toward digital documents, including almost every scientific publication. If updates are done properly, a DOI will always resolve to a document, even if that document gets shifted to a new URL. But it also has a way of handling documents disappearing from their expected location, as might happen if a publisher went bankrupt. There are a set of what's called "dark archives" that the public doesn't have access to, but should contain copies of anything that's had a DOI assigned. If anything goes wrong with a DOI, it should trigger the dark archives to open access, and the DOI updated to point to the copy in the dark archive. For that to work, however, copies of everything published have to be in the archives. So Eve decided to check whether that's the case.

Using the Crossref database, Eve got a list of over 7 million DOIs and then checked whether the documents could be found in archives. He included well-known ones, like the Internet Archive at archive.org, as well as some dedicated to academic works, like LOCKSS (Lots of Copies Keeps Stuff Safe) and CLOCKSS (Controlled Lots of Copies Keeps Stuff Safe). The results were... not great. When Eve broke down the results by publisher, less than 1 percent of the 204 publishers had put the majority of their content into multiple archives. (The cutoff was 75 percent of their content in three or more archives.) Fewer than 10 percent had put more than half their content in at least two archives. And a full third seemed to be doing no organized archiving at all. At the individual publication level, under 60 percent were present in at least one archive, and over a quarter didn't appear to be in any of the archives at all. (Another 14 percent were published too recently to have been archived or had incomplete records.)

The good news is that large academic publishers appear to be reasonably good about getting things into archives; most of the unarchived issues stem from smaller publishers. Eve acknowledges that the study has limits, primarily in that there may be additional archives he hasn't checked. There are some prominent dark archives that he didn't have access to, as well as things like Sci-hub, which violates copyright in order to make material from for-profit publishers available to the public. Finally, individual publishers may have their own archiving system in place that could keep publications from disappearing. The risk here is that, ultimately, we may lose access to some academic research.

Astronomers have observed a distant planet that could be entirely covered in a deep water ocean, in findings that advance the search for habitable conditions beyond Earth. From a report: The observations, by Nasa's James Webb space telescope (JWST), revealed water vapour and chemical signatures of methane and carbon dioxide in the atmosphere of the exoplanet, which is twice Earth's radius and about 70 light years away. This chemical mix is consistent with a water world where the ocean would span the entire surface, and a hydrogen-rich atmosphere, according to researchers from the University of Cambridge, although they do not envisage a balmy, inviting seascape. "The ocean could be upwards of 100 degrees [Celsius] or more," said Prof Nikku Madhusudhan, who led the analysis. At high atmospheric pressure, an ocean this hot could still be liquid, "but it's not clear if it would be habitable," he added.

This interpretation is favoured in a paper published in the journal Astronomy and Astrophysics Letters, but is disputed by a Canadian team that made additional observations of the same exoplanet, which is known as TOI-270 d. They detected the same atmospheric chemicals but argue the planet would be too hot for liquid water -- possibly 4,000C -- and instead would feature a rocky surface topped by an incredibly dense atmosphere of hydrogen and water vapour. Whichever view wins out, these latest observations showcase the stunning insights James Webb is giving into the nature of planets beyond our solar system. The telescope captures the starlight that has been filtered through the atmospheres of orbiting planets to give detailed breakdowns of the chemical elements present. From this, astronomers can build up a picture of conditions at a planet's surface -- and the likelihood of life being able to survive there.

Mexico is waiting for the United States to provide evidence that shows imported genetically modified corn is safe for human consumption. "In a written submission to a panel of the United States-Mexico-Canada Agreement, Mexico, the top buyer of U.S. corn, argued that science proves GM corn and the herbicide glyphosate are harmful to human health and its native varieties, and that its decree to ban GM corn for human consumption is within its right," reports Reuters. From the report: [Deputy Agriculture Secretary Victor Suarez] said the onus is now on the United States to show GM corn is not harming Mexico's population, which consumes a higher amount of corn than many countries through daily diet staples like nixtamalized dough and tortilla. The United States "argues that the decisions in Mexico are not based on science and that their decisions are," Suarez told Reuters in an interview. "But we still haven't seen the science of the United States or the companies. We are looking forward to that study with great pleasure."

A spokesman for the U.S. Department of Agriculture said Mexico's approach to biotechnology runs counter to "decades' worth of evidence demonstrating its safety." A senior official for the U.S. Trade Representative said, "Scientific authorities, including in Mexico, have consistently found biotech products like corn to be safe over a period of decades." [...] Mexico's written response cited studies it said showed links between GM corn consumption and glyphosate exposure to liver inflammation in people and impacts to immune response in animals, saying it considers the risk to human health "extremely serious."

The United States in August requested a dispute settlement panel under the USMCA over Mexico's decree to ban GM corn for human consumption, specifically in the use of making flour for tortillas. The decree allows the use of GM yellow corn in animal feed, which accounts for the majority of Mexico's nearly $5.9 billion worth of U.S. corn imports annually. Washington argues Mexico's decree banning imports of GM corn used for tortillas is not based on science and violates its commitments under the USMCA, which has been in place since 2020. "There is no impact on trade," Suarez said of Mexico's decree. "The value and volume of exports of GM corn to Mexico has increased."

Mexico's decree also calls for the gradual substitution of GM corn, a point of contention highlighted by U.S. officials. In its written response, Mexico argued that no specific time frame has been established and therefore it has had no trade impact. "It is a strategic goal, like the United States would like to have energy sovereignty and energy self-sufficiency," Suarez said. The United States is expected to issue a rebuttal to Mexico's response.

An anonymous reader quotes a report from The Guardian: Doctors have warned of potentially life-threatening effects from plastic pollution after finding a substantially raised risk of stroke, heart attack and earlier death in people whose blood vessels were contaminated with microscopic plastics. Researchers in Naples examined fatty plaques removed from the blood vessels of patients with arterial disease and found that more than half had deposits contaminated with tiny particles of polyethylene or polyvinyl chloride (PVC). Those whose plaques contained microplastics or nanoplastics were nearly five times more likely to suffer a stroke, heart attack or death from any cause over the following 34 months, compared with those whose plaques were free from plastic contamination. The findings do not prove that plastic particles drive strokes and heart attacks -- people who are more exposed to the pollution may be at greater risk for other reasons -- but research on animals and human cells suggests the particles may be to blame. [...]

Writing in the New England Journal of Medicine, the doctors describe how they analyzed fatty plaques removed from 304 patients with atherosclerosis affecting the carotid arteries. The carotid arteries are the main blood vessels that supply blood to the neck, face and brain. The disease causes a build-up of plaque in the arteries, which substantially raises the risk of stroke. The plaques can be removed by a procedure called carotid endarterectomy. Lab tests on the extracted plaques revealed polyethylene in 150 patients and polyvinyl chloride in 31, alongside signs of inflammation. On examination under an electron microscope, the researchers spotted jagged foreign particles in the fatty deposits, most less than a thousandth of a millimeter across. The doctors followed 257 of the patients for an average of 34 months after they had carotid plaques removed. Those who had plastic particles in their plaques were 4.5 times more likely to have a stroke or heart attack, or to die from any cause, than those whose plaques were free from plastic pollution. "People must become aware of the risks we are taking with our lifestyle," said Dr Raffaele Marfella, first author on the study at the University of Campania Luigi Vanvitelli in Naples. "I hope the alarm message from our study will raise the consciousness of citizens, especially governments, to finally become aware of the importance of the health of our planet. To put it in a slogan that can unite the need for health for humans and the planet, plastic-free is healthy for the heart and the Earth."

John Timmer reports via Ars Technica: A company called Colossal plans to pioneer the de-extinction business, taking species that have died within the past few thousand years and restoring them through the use of DNA editing and stem cells. It's grabbed headlines recently by announcing some compelling targets: the thylacine, an extinct marsupial predator, and an icon of human carelessness, the dodo. But the company was formed to tackle an even more audacious target: the mammoth, which hasn't roamed the Northern Hemisphere for thousands of years. Obviously, there are a host of ethical and conservation issues that would need to be worked out before Colossal's plans go forward. But there are some major practical hurdles as well, most of them the product of the distinct and extremely slow reproductive biology of the mammoth's closest living relatives, the elephants. At least one of those has now been cleared, as the company is announcing the production of the first elephant stem cells. The process turned out to be extremely difficult, suggesting that the company still has a long road ahead of it. [...] Overall, it's a project that has a high probability of failure and may ultimately require generations of scientists. If we do successfully de-extinct a species, the first example will probably be a different species, even though the projects launched later.

But Colossal is forging ahead and cleared one of the many hurdles it faces: It created the first induced stem cells from elephants and will be placing a draft manuscript describing the process on a public repository on Wednesday. (Colossal provided Ars with an advanced version of the draft that, outside of a few editing errors, appears largely complete.) Beyond providing the technical details of how the process works, the manuscript describes a long, failure-ridden route to eventual success. Several methods have been developed to allow us to induce stem cells from the cells of an adult organism. The original Nobel-winning process developed by Shinya Yamanaka involved inserting the genes that encode four key embryonic regulatory genes into adult cells and allowing them to reprogram the adult cell into an embryonic state. That has proven effective in a variety of species but has a couple of drawbacks due to the fact that the four genes can potentially stick around, interfering with later development steps. Although there are ways around that, others have developed a cocktail of chemicals that perform a similar function by activating signaling pathways that, collectively, can also reprogram adult cells. When it works, this simplifies matters, as you only have to remove the chemicals to allow the stem cells to adopt other fates. Colossal tried both of these. Neither worked with elephant cells: "Multiple attempts with current standard reprogramming methods were tried, and failed, and resulted in no, or incomplete, reprogramming." Apparently, lots of additional trial and error ensued. The eventual solution ended up being based in part on combining the two primary options: Cells were first exposed to a chemical reprogramming cocktail and then given the four genes used in the alternative reprogramming method. On its own, however, that wasn't enough. The researchers also had to address a quirk of elephant biology.

Obviously, for Colossal, this is a means to an end: the mammoth. But that's remarkably underplayed in the manuscript. Instead, its emphasis is on the technology's use in the conservation of existing species. [T]he researchers note that studying things like elephant development and metabolism in actual elephants is not especially realistic. But we can potentially induce the stem cells developed here into any cell we'd want to study -- nerve, liver, heart, and so on. So, the stem cells described here could be a useful tool for research. So, these cells are being presented as a valuable tool for the research community. Still, you can expect the people behind the de-extinction project to be getting to work on some of the easier things: showing that the genome in the cells can be edited and that they can be induced to start the process of embryogenesis. Separately, some unfortunate individuals will need to be working on the hard problems we mentioned earlier.

The 46-year-old probe, which flew by Jupiter and Saturn in its youth and inspired earthlings with images of the planet as a "Pale Blue Dot," hasn't sent usable data from interstellar space in months. From a report: When Voyager 1 launched in 1977, scientists hoped it could do what it was built to do and take up-close images of Jupiter and Saturn. It did that -- and much more. Voyager 1 discovered active volcanoes, moons and planetary rings, proving along the way that Earth and all of humanity could be squished into a single pixel in a photograph, a "pale blue dot," as the astronomer Carl Sagan called it. It stretched a four-year mission into the present day, embarking on the deepest journey ever into space. Now, it may have bid its final farewell to that faraway dot.

Voyager 1, the farthest man-made object in space, hasn't sent coherent data to Earth since November. NASA has been trying to diagnose what the Voyager mission's project manager, Suzanne Dodd, called the "most serious issue" the robotic probe has faced since she took the job in 2010. The spacecraft encountered a glitch in one of its computers that has eliminated its ability to send engineering and science data back to Earth. The loss of Voyager 1 would cap decades of scientific breakthroughs and signal the beginning of the end for a mission that has given shape to humanity's most distant ambition and inspired generations to look to the skies.

More than one-quarter of scholarly articles are not being properly archived and preserved, a study of more than seven million digital publications suggests. From a report: The findings, published in the Journal of Librarianship and Scholarly Communication on 24 January, indicate that systems to preserve papers online have failed to keep pace with the growth of research output. "Our entire epistemology of science and research relies on the chain of footnotes," explains author Martin Eve, a researcher in literature, technology and publishing at Birkbeck, University of London. "If you can't verify what someone else has said at some other point, you're just trusting to blind faith for artefacts that you can no longer read yourself."

Eve, who is also involved in research and development at digital-infrastructure organization Crossref, checked whether 7,438,037 works labelled with digital object identifiers (DOIs) are held in archives. DOIs -- which consist of a string of numbers, letters and symbols -- are unique fingerprints used to identify and link to specific publications, such as scholarly articles and official reports. Crossref is the largest DOI registration agency, allocating the identifiers to about 20,000 members, including publishers, museums and other institutions.

The sample of DOIs included in the study was made up of a random selection of up to 1,000 registered to each member organization. Twenty-eight percent of these works -- more than two million articles -- did not appear in a major digital archive, despite having an active DOI. Only 58% of the DOIs referenced works that had been stored in at least one archive. The other 14% were excluded from the study because they were published too recently, were not journal articles or did not have an identifiable source.

Clare Watson reports via ScienceAlert: By replacing the hazardous chemical electrolytes used in commercial batteries with water, scientists have developed a recyclable 'water battery' -- and solved key issues with the emerging technology, which could be a safer and greener alternative. 'Water batteries' are formally known as aqueous metal-ion batteries. These devices use metals such as magnesium or zinc, which are cheaper to assemble and less toxic than the materials currently used in other kinds of batteries.

Batteries store energy by creating a flow of electrons that move from the positive end of the battery (the cathode) to the negative end (the anode). They expend energy when electrons flow the opposite way. The fluid in the battery is there to shuttle electrons back and forth between both ends. In a water battery, the electrolytic fluid is water with a few added salts, instead of something like sulfuric acid or lithium salt. Crucially, the team behind this latest advancement came up with a way to prevent these water batteries from short-circuiting. This happens when tiny spiky metallic growths called dendrites form on the metal anode inside a battery, busting through battery compartments. [...]

To inhibit this, the researchers coated the zinc anode of the battery with bismuth metal, which oxidizes to form rust. This creates a protective layer that stops dendrites from forming. The feature also helps the prototype water batteries last longer, retaining more than 85 percent of their capacity after 500 cycles, the researchers' experiments showed. According to Royce Kurmelovs at The Guardian, the team has so far developed water-based prototypes of coin-sized batteries used in clocks, as well as cylindrical batteries similar to AA or AAA batteries. The team is working to improve the energy density of their water batteries, to make them comparable to the compact lithium-ion batteries found inside pocket-sized devices. Magnesium is their preferred material, lighter than zinc with a greater potential energy density. [I]f magnesium-ion batteries can be commercialized, the technology could replace bulky lead-acid batteries within a few years. The study has been published in the journal Advanced Materials.

Andrew Jones reports via SpaceNews: The China Aerospace Science and Technology Corporation (CASC) plans to launch four-meter and five-meter-diameter reusable rockets for the first time in 2025 and 2026 respectively, Wang Wei, a deputy to the National People's Congress, told China News Service March 4. The reports do not clearly identify the two rockets. CASC is known to be developing a new, 5.0m-diameter crew launch vehicle, known as the Long March 10. A single stick version would be used to launch a new-generation crew spacecraft to low Earth orbit and could potentially fly in 2025. A three-core variant will launch the "Mengzhou" crew spacecraft into trans-lunar orbit.

The rocket is key to China's plans to put astronauts on the moon before 2030. The Long March 10 lunar variant will be 92 meters long and be able to launch 27 tons into trans-lunar orbit. The 4.0-meter-diameter launcher could be a rocket earlier proposed by CASC's Shanghai Academy of Spaceflight Technology (SAST). That rocket would be able to launch up to 6,500 kg of payload to 700-kilometer sun-synchronous orbit (SSO). It would notably use engines developed by the commercial engine maker Jiuzhou Yunjian.

CASC's first move to develop a reusable rocket centered on making a recoverable version of the Long March 8. That plan appears to have been abandoned. SAST also plans to debut the 3.8m-diameter Long March 12 later this year from a new commercial launch site. While the Long March 10 has specific, defined uses for lunar and human spaceflight, the second reusable rocket would appear to be in competition with China's commercial rocket companies. While this suggests duplication of effort, it also fits into a national strategy to develop reusable rockets and support commercial ecosystems. The moves would greatly boost China's options for launch and access to space. It would also provide new capacity needed to help construction planned low Earth orbit megaconstellations.